Recent Developments in the Medicinal Applications of Silver-NHC Complexes and Imidazolium Salts

Recent Developments in the Medicinal Applications of Silver-NHC Complexes and Imidazolium Salts

Blog Article

Because of their great structural diversity and multitude of chemical properties, N-heterocyclic carbenes (NHCs) have been utilized in a variety of capacities.Most recently, NHCs have been utilized as copyright molecules for many transition metals in medicinal chemistry.Specifically, Ag(I)-NHCs have been investigated as potent antibacterial agents and chemotherapeutics and have shown great efficacy in both in vitro and in vivo studies.Ag(I)-NHC compounds have been shown Rough Rider to be effective against a wide range of both Gram-positive and Gram-negative bacterial strains.

Many compounds have also shown great efficacy as antitumor agents demonstrating comparable or better antitumor activity than standard chemotherapeutics such as cisplatin and 5-fluorouracil.While these compounds have shown great promise, clinical use has remained an unattained goal.Current research has been focused upon synthesis of novel Ag(I)-NHC compounds and further Hunting Gloves investigations of their antibacterial and antitumor activity.This review will focus on recent advances of Ag(I)-NHCs in medicinal applications.